Revista médica de Chile
versión ISSN 0034-9887
SOTO V, Álvaro y CARTIER R, Luis. Acute encephalopathy associated with the use of intravenous immunoglobulin. Report of one case. Rev. méd. Chile [online]. 2011, vol.139, n.10, pp. 1340-1343. ISSN 0034-9887. doi: 10.4067/S0034-98872011001000014.
Adverse reactions to intravenous immunoglobulin (ivIg) therapy, such as anaphylaxis, acute encephalopathy, aseptic meningitis, or thrombotic phenomena are uncommon. We report a 58-year-old man with hypertension presenting with muscle weakness which led to paraparesia and respiratory failure. With the diagnosis of Guillain-Barré syndrome (GBS), he was treated with ivIg. He developed an acute encephalopathy few hours after the administration of ivIg, with a decreased level of consciousness and agitation. A CT scan revealed moderate and diffuse brain edema. Encephalopathy resolved 96 hours after ivIg withdrawal and use of plasma exchange. A CT scan performed seven days after showed the resolution of brain edema.
Palabras clave : Guillain-Barré syndrome; Immunoglobulin intravenous; Neurotoxicity syndromes.