Revista médica de Chile
versión ISSN 0034-9887
SANHUEZA, Jorge A; HERRERA, Christian L; SALAZAR, Luis A y SILVA, Jaime R. CRF-BP and SLC6A4 gene polymorphisms among restrained eaters. Rev. méd. Chile [online]. 2011, vol.139, n.10, pp. 1261-1268. ISSN 0034-9887. doi: 10.4067/S0034-98872011001000003.
Background: Restrained eaters (RE) are a group of individuals who constantly restrict their eating. However, they usually alternate restriction with periods of overeating. Aim: To evaluate the possible association of CRF-BP and SLC6A4 gene polymorphisms with chronic alimentary restriction. Material and Methods: The Spanish version of the Revised Restraint Scale was applied to 132 women aged 18 to 25 years. They were divided in a group classified as restrained eaters (RE) and a group of unrestrained eaters. The 5-HTTLPR and CRF-BPs11 polymorphisms of the SLC6A4 and CRF-BP genes were evaluated by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP), respectively. Results: There was a significant association between the s/s homozygous genotype for the 5-HTTLPR polymorphism of SLC6A4 gene and RE condition (p = 0.033). However, this association was not observed for the CRF-BPs11 polymorphism. Conclusions: The presence of s/s genotype is associated with the RE condition, being the presence of a s allele, a risk factor for this condition.
Palabras clave : Eating disorders; GABA plasma membrane transport proteins; Polymorphism, genetic.