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Revista médica de Chile
versión impresa ISSN 0034-9887
QUERALES, MARVIN ISAAC; CRUCES, MARÍA ELENA; ROJAS, SUSAN y SANCHEZ, LISSETTE. Association between vitamin D deficiency and metabolic syndrome. Rev. méd. Chile [online]. 2010, vol.138, n.10, pp.1312-1318. ISSN 0034-9887. http://dx.doi.org/10.4067/S0034-98872010001100017.
Vitamin D has an essential role in calcium metabolism and bone health. Vitamin D3 or cholecalciferol is synthesized from 7-dehydrocholesterol or provitamin D3, by sunlight ultraviolet radiation to the skin. 7-dehydrocholesterol is subsequently hydroxylated in the liver and then in the kidney to produce 1,25-(OH)2D3, the active metabolite that binds to specific receptors (VDR) in target tissues, mainly bone and intestine. Other tissues, such as the immune and cardiovascular system, have also VDR. Vitamin D deficiency can induce rickets in children and osteomalacia and osteoporosis in adults. A possible inverse association between vitamin D levels and the prevalence of metabolic syndrome has been proposed. Vitamin D deficiency increases the risk of type 1 diabetes, insulin resistance, and hypertension, key components of this syndrome. However, other studies have not confirmed this association. Further clinical and experimental studies are needed to ascertain the role of vitamin D in metabolic syndrome.
Palabras clave : Insulin resistance; Vitamin D; Metabolic syndrome X.