Revista médica de Chile
versión impresa ISSN 0034-9887
MULLER, Bettina et al. Results of adjuvant chemoradiation after curative surgery for gastric cancer: A retrospective study. Rev. méd. Chile [online]. 2009, vol.137, n.5, pp. 649-656. ISSN 0034-9887. doi: 10.4067/S0034-98872009000500008.
Background: Survival rates after curative surgery for gastric cancer are disappointing. Therefore adjuvant therapeutic strategies are required. Aim: To analyze survival and side effects of treatment among gastric cancer patients treated with adjuvant chemo radiotherapy after curative resection of gastric adenocarcinoma. Material and methods: Retrospective review of medical records of 74 patients aged 20 to 74 years, treated with complete resection of gastric adenocarcinoma followed by adjuvant chemo radiation. Survival analysis was based on the records and information from the National Mortality Registry. Results: Five years survival fluctuated from 50% among patients in stage IB to 25% among those is stage IV. Significant acute toxicity was observed in 23 patients (31%). No patients died due to acute toxicity. Eleven patients (16.4%) developed significant late toxicity, with two possible deaths related to treatment. Conclusions: Postoperative chemo radiotherapy is feasible in our experience. Continues infusion of 5-fluoruracil is recommended to reduce toxicity.
Palabras clave : Antineoplastic protocols; Radiotherapy adjuvant; Stomach neoplasms.