SciELO - Scientific Electronic Library Online

 
vol.137 número5Violencia sexual en hombres y mujeres jóvenes en Chile: Resultados de una encuesta (año 2005) a estudiantes universitariosMejoría en las habilidades de comunicación escrita de estudiantes de medicina: Impacto de un taller de escritura índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Articulo

Indicadores

Links relacionados

Compartir


Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

GARCIA D, Diego et al. Association of GHRd3 variant of growth hormone receptor gene with autoimmunity in type 1 diabetes. Rev. méd. Chile [online]. 2009, vol.137, n.5, pp. 609-616. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872009000500003.

Background: Growth Hormone Receptor (GRH) is expressed in the liver, pancreas, stomach and small intestine. A high expression of GHR mRNA in the mucosal gut suggests a possible role of this receptor on digestive and immune functions. Aim: To investigate the putative effects of the GHRd3 variants on the cytokine profile and distribution of auto-antibodies in children with type 1 diabetes (T1D). Material and Methods: Unrelated unaffected controls (n =192) and incident cases of children with T1D (n =127) were analyzed for GHRd3 polymorphism, cytokine profile and a panel of auto-antibodies. Results: The allele frequency for d3 was 24.8% in type 1 diabetics and 34.1% in controls (p =NS). Among type 1 diabetic children, the carriers of the GHRd3 polymorphism had significantly higher levels of interleukin-lB than homozygous for the wild type genotype (5.7 and 17.7, pg/ml respectively p <0.015). Carriers of d3 variant had a higher frequency of positive anti-insulin antibodies (anti-IAA) than children without this variant (39.6 and 17.7% respectively, p <0.01). Conclusions: The observed frequency of the GHR d3/d3 genotype was comparable to other reports. A relationship between d3 variant and anti-IAA antibodies and interleukin-lß was observed.

Palabras clave : Diabetes mellitus, Type 1; Cytokines; Human growth hormone.

        · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons