Revista médica de Chile
versión impresa ISSN 0034-9887
ARCHIBALDO DONOSO, S y DELGADO D, Carolina. Prevention and treatment of Alzheimer disease. Rev. méd. Chile [online]. 2009, vol.137, n.2, pp. 289-295. ISSN 0034-9887. doi: 10.4067/S0034-98872009000200016.
The pharmacological interventions for Alzheimer disease should be based in its pathogenic mechanisms such as amyloidogenesis, tau hyperphosphorilation, disturbances in neurotransmission and changes in neuronal trophism. Other therapies derive from epidemiological observations, such as antioxidants and anti-inflammatory drugs, estrogens, statins and anti hypertensive drugs. Some life style interventions, such as changes in diet, exercise and brain stimulation could also be beneficial for the prevention of Alzheimer disease. Ongoing research on pathogenic mechanisms promises the discovery of more effective therapies. Healthy life style should always be recommended due to its benefit and lack of untoward effects.
Palabras clave : Alzheimer disease; Amyloid; Life style.