Revista médica de Chile
versión impresa ISSN 0034-9887
BOCANEGRA-PEREZ, Sacramento et al. Osteonecrosis of the jaw secondary to oral alendronate: Report of three cases. Rev. méd. Chile [online]. 2009, vol.137, n.2, pp.275-279. ISSN 0034-9887. http://dx.doi.org/10.4067/S0034-98872009000200014.
Osteonecrosis of the jaw associated to biphosphonate use is more common in cancer patients with bone metastases, that are using intravenous diphosphonates. When these drugs are used orally the risk of the complication is lower. We report 3 diabetic women aged 69, 76 and 82 years, receiving alendronate 70 mg every one week. The unveiling event was the extraction of several teeth without the use of antibiotics. All had bone pain, purulent discharge, loss of bone and halitosis. All improved five months after discontinuing alendronate.
Palabras clave : Alendronates; Biphosphonates; Osteonecrosis.