Revista médica de Chile
versión impresa ISSN 0034-9887
QUINONES S, Luis et al. Role of cytochrome P450 enzymes in the metabolism of antineoplastic drugs. Rev. méd. Chile [online]. 2008, vol.136, n.10, pp. 1327-1335. ISSN 0034-9887. doi: 10.4067/S0034-98872008001000015.
Cytochrome P450 enzymes are very important to metabolize anti-carcinogenic agents. Therefore, understanding the role of these enzymes and their allele variants in the bioactivation or detoxification of drugs could greatiy benefit antineoplastic pharmacotherapy. The aim of thís manuscrípt is to give information about metabohzing enzymes for antineoplastic agents and to relate the current situation in antitumoral pharmacotherapy with recent knowledge about cytochrome P450 enzymes. This is crucial for the future perspectives towards personalized pharmacotherapy. We summarize the role of cytochrome P450 enzymes in the resistance and bioactivation of several antitumor agents, their induction and repression mechanisms and the effect of genetic polymorphisms on variability of drug metabolization. The understanding of genetic variability will help to develop new research Unes on innovative therapeutic possibilities.
Palabras clave : Antineoplastic drugs; Cytochrome P450 enzyme system; Polymorphism, genetic.