Revista médica de Chile
versión impresa ISSN 0034-9887
ERAZO B, Marcia; AMIGO C, Hugo; OYARZUN G, Manuel y PERUGA U, Armando. Smoking and Lung Cancer: Attributable risks according to gender. Rev. méd. Chile [online]. 2008, vol.136, n.10, pp. 1272-1280. ISSN 0034-9887. doi: 10.4067/S0034-98872008001000006.
Background: The association between Lung Cancer and smoking is well documented. However there is less information about the estimation of its attributable fraction and population burden. Aim: To estímate the attributable risk and population attributable risk of smoking among Lung Cancer patients attended in Public Health Services at Santiago. Material and methods: A case control study matched by age was carried out. Crude and adjusted attributable and population attributable risks were estimated, controlling for potential confounders and interaction variables. Results: Mean age for cases was 63 years for women and 67 years for men. Lung Cancer patients had a higher smoking prevalence than controls (64.5% and 39.7% respectively among women; 95.8 and 67.1 respectively among men p <0.01). Heavy smoker proportion was 4 times higher among patients that smoked 5 to 10 years more (women and men respectively, p <0.01) and 3 times more cigarettes per day (p <0.01). Attributable risk for women was 64.4% and 90.4% for men. Population attributable fraction was 41.9% and 86.3% for women and men, respectively. Projecting these estimates to the Chilean population, approximately 1975 new cases per year of Lung Cancer caused by smoking will be diagnosed. Conclusions: Attributable risks of smoking for Lung Cancer are high and significant, even when they are adjusted by confounding variables.
Palabras clave : Lungneoplasms; Smoking; Tobáceo smoke pollution.