SciELO - Scientific Electronic Library Online

 
vol.136 número4Análisis de la aceptabilidad, consumo y aporte nutricional del programa alimentario del adulto mayorValidación de ecuaciones antropométricas para evaluar composición corporal en niños preescolares chilenos índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

PEREZ I, Alfonso et al. Presence of metal lo ß-lactamases in imipenem-resistant Pseudomonas aeruginosa. Rev. méd. Chile [online]. 2008, vol.136, n.4, pp. 423-432. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872008000400002.

Background: Metallo-ß-lactamases (MBL) confer high resistance to carbapenems in Pseudomonas aeruginosa (Psae). They are encoded in mobile elements of different genes (VIM, IMP, SMP, GIM), along with other resistance genes. Aim: To detect the presence of MBL in imipenem resistant Psae strains. Material and methods: Fifty-nine imipenem resistant Psae strains isolated from January 2004 to August 2005 in a University Clinical Hospital, were included. The presence of MBL was studied by Etest (phenotypic) and genotypic polymerase chain reaction (PCR) methods. To rule out a nosocomial outbreak, MBL positive strains, were studied by pulse field gel electrophoresis. Results: The presente of MBL was detected in eleven strains. AH were type VIM and were not clonally related. There was no concordance between phenotypic and genotypic MBL detecting methods. AH the strains were also multiresistant. Conclusions: The presence of MBL was detected in 19% of imipenem resistant Psae strains

Palabras llave : Beta-Lactamases; Imipenem; Pseudomonas aeruginosa.

        · texto en Español     · pdf en Español