Revista médica de Chile
versión impresa ISSN 0034-9887
VALERO C, Nereida; REYES V, Ivette; LARREAL E, Yraima y MALDONADO E, Mery. Aminotransferases serum levels in patients with Dengue type 3. Rev. méd. Chile [online]. 2007, vol.135, n.10, pp. 1304-1312. ISSN 0034-9887. doi: 10.4067/S0034-98872007001000011.
Background: Dengue infections may affect the liver, causing inflammation and compromising its function. Aim: To determine serum aminotransferases in patients with Dengue. Material and methods: One hundred eighty four patients with Dengue confirmed with anti-Dengue IgG and IgM antibodies measured by ELISA, aged 1 month to 79 years, were studied. As controls, 40 patients with acute hepatitis B virus infection aged 11 to 59 years and 40 healthy individuals, aged 14 to 55 years, were also studied. Alanine and aspartate aminotransferases (ALT and AST) were determined using a colorimetric method. Results: Sixty one percent of patients with Dengue had elevated aminotransferase levels. In patients with Dengue and hepatitis B, mean ALT levels were 21.3±8.4 and 29.7±18.8 U/I, respectively. Mean AST values were 37.3±19, 19.6± 16.4 and 4.3±1.7 U/I in patients with Dengue, hepatitis B and controls, respectively. During the year 2001, there was an increase in the number of cases with hemorrhagic fever caused by Dengue and 65% had elevation of aminotransferases. Conclusions: An increase in aminotransf erase levels is common in patients with Dengue
Palabras clave : Dengue hemorrhagic fever; Hepatitis, viral, human; Transaminases.