Revista médica de Chile
versión impresa ISSN 0034-9887
ALVAREZ-LOBOS, Manuel et al. Tumor necrosis factor receptor associated periodic syndrome (TRAPS): Report of two cases. Rev. méd. Chile [online]. 2006, vol.134, n.12, pp. 1558-1561. ISSN 0034-9887. http://dx.doi.org/10.4067/S0034-98872006001200010.
Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS) is an autoinflammatory disorder associated to a mutation of the Tumor Necrosis Factor Receptor 1 (TNFR1) whose clinical presentation consists on recurrent episodes of prolonged fever, abdominal pain, myalgias, migratory cutaneous erythema, conjunctivitis or periorbitary edema. The diagnosis is confirmed by genetic analysis of the TNFR1 gene. Its main complication is amyloidosis and the treatment is based on the use of corticosteroids or anti-TNF antibodies. We report a 17 year-old male and 23 year-old female with the syndrome. Both cases had heterozygous mutations of the TNFR1 gene, C30R in the first case and T50M in the second case
Palabras llave : Amyloidosis; Cytogenetic analysis; Receptors, Tumor Necrosis Factor, type I.