Revista médica de Chile
versão impressa ISSN 0034-9887
GELLONA V, José et al. Infliximab in the treatment of patients with Crohn's disease: Preliminary report . Rev. méd. Chile [online]. 2006, vol.134, n.3, pp. 320-325. ISSN 0034-9887. doi: 10.4067/S0034-98872006000300008.
Background: Tumor necrosis factor alpha, interleukin 6 and 1 have a pathogenic role in Crohn's disease. Infliximab, a monoclonal antibody against tumor necrosis factor, is useful in the treatment of Crohn's disease, specially when the disease is active and associated to fistula formation. Aim: To assess the effectiveness of Infliximab in patients with Crohn's disease. Material and methods: Twelve patients with Crohn's disease (aged 16 to 63 years, 10 women) refractory to treatment with steroid, 5-aminosalicylic acid, antimicrobials and immunomodulatory drugs, were studied. A single intravenous 5 mg/kg dose Infliximab was administered. The Crohn's disease activity index (CDAI) was measured before and one week after the administration of the drug. Results: CDAI before and after Infliximab administration was 357±62 and 138±122 score points, respectively (p <0.005). According to this score, five patients had a severe and seven a moderate disease flare. The disease remitted in 7 (58%) and a clinical response was observed in 75%. Conclusions: A single dose of Infliximab was effective to induce remission of the disease in 75% of this selected group of patients with Crohn's disease
Palavras-chave : Antibodies, monoclonal; Crohn's disease; Infliximab; Tumor necrosis factor-alpha.