Revista médica de Chile
versión impresa ISSN 0034-9887
NAZER H, Julio; AGUILA R, Alfredo y CIFUENTES O, Lucía. The frequency of twin pregnancies increased in a Chilean hospital associated with periconceptional flour folic acid supplementation. Rev. méd. Chile [online]. 2006, vol.134, n.1, pp. 48-52. ISSN 0034-9887. doi: 10.4067/S0034-98872006000100006.
Background: A significant increase in the frequency of twins has been described in the literature as a secondary effect of perinatal supplementation with folic acid. Aim: To verify if the frequency of twins increased in a Chilean hospital, after the start of flour folic acid supplementation. Material and methods: The frequency of twins was compared in the University of Chile Clinical Hospital, before and after the start of flour fortification with folic acid. Results: There was a 34% increase in the frequency of twins during the post fortification period (2001-2004) as compared with the previous period (1998-2000). A decrease in the frequency of male twins, when compared with single newborns, was also observed in the post fortification period. There was a higher frequency of stillborns among twins, when compared with single newborns. Conclusions: The frequency of twin pregnancies increased after flour folic acid supplementation in sample of Chilean population
Palabras clave : Dietary supplements; Flour; Folic acid; Pregnancy, multiple; Twins.