Revista médica de Chile
versión impresa ISSN 0034-9887
SILVA O, Francisco; DURAN T, Claudia; ULLOA F, María Teresa y PRADO J, Valeria. Activity of cefpodoxime against pathogens causing respiratory, urinary or soft tissue infections. Rev. méd. Chile [online]. 2005, vol.133, n.8, pp.903-910. ISSN 0034-9887. http://dx.doi.org/10.4067/S0034-98872005000800006.
Background: Cefpodoxime is a new antimicrobial in the Chilean market, recommended for treatment of respiratory and urinary tract infections. Aim: To study the susceptibility of common pathogens isolated from Chilean patients to cefpodoxime and other antimicrobials. Material and methods: The in vitro activity of cefpodoxime, expressed as Minimal Inhibitory Concentration, was studied in 331 S pneumoniae, H influenzae, M catarrhalis, E coli, S aureus and S pyogenes strains, isolated between 2000 and 2004 from respiratory, urinary and soft tissue infections, respectively. Results: Eleven percent of S pneumoniae isolates were resistant to penicillin, 11% were resistant to cefuroxime and 10% to cefpodoxime. All H influenzae isolates were susceptible to cefpodoxime. No H influenzae isolates were resistant to second or third generation cephalosporines. Four percent of H influenzae isolates were resistant to ampicillin by ß-lactamase production. In contrast 81% of M catarrhalis strains were resistant to ampicillin. Six percent of E coli isolates were resistant to cefpodoxime, 9% to cefuroxime, 11% to cefadroxile and 50% to ampicillin or trimethoprim/sulphamethoxazole. Cefpodoxime was the most active antimicrobial against S pyogenes. Conclusions: Cefpodoxime, recently introduced in Chile, is a good alternative for the treatment of common respiratory and urinary tract infections
Palabras clave : Cefpodoxime; Cephalosporins; Drug resistance, bacterial; Respiratory tract infections; Urinary tract infections.