Revista médica de Chile
versión impresa ISSN 0034-9887
ALFARO L, Jorge et al. Intravascular lymphoma treated with anti CD20 monoclonal antibodies: Report of one case. Rev. méd. Chile [online]. 2004, vol.132, n.11, pp. 1403-1406. ISSN 0034-9887. doi: 10.4067/S0034-98872004001100010.
We report a 78 year old male with prostatism, that was subjected to a prostate biopsy. The pathological study showed a microvascular lymphocytic infiltration. Four months later, the patients presentd with reduced alertness, cough, dyspnea, fever and elevation of lactic dehydrogenase and erythrocyte sedimentation rate. Chest and abdominal CAT scans, bone marrow aspirate, protein electrophoresis and prostate specific antigen were normal. A re-evaluation of prostate biopsy showed an intravascular lymphoid infiltration, positive for CD45 and CD20, compatible with the diagnosis of intravascular lymphoma. Chemotherapy was started, but it was not tolerated by the patient and the response was partial. Therefore, treatment with monoclonal antibodies anti CD20 (Rituximab) was started. The tumor had a complete and prolonged (24 months) remission after the treatment
Palabras clave : Antibodies; monoclonal; CD20 antigens; Lymphoma; non-Hodgkin.