Revista médica de Chile
Print version ISSN 0034-9887
ORDONEZ A, María Paz; NAZER H, Julio; AGUILA R, Alfredo and CIFUENTES O, Lucía. Association between congenital malformations and chronic diseases of the mother. Rev. méd. Chile [online]. 2003, vol.131, n.4, pp. 404-411. ISSN 0034-9887. doi: 10.4067/S0034-98872003000400008.
Background: Several maternal diseases, such as diabetes mellitus or high blood pressure, are associated with a higher risk for fetal or neonatal problems. Aim: To study the association between chronic diseases of the mother and congenital malformations. Material and methods: Review of the records of the Latin American Collaborative Study of Congenital Malformations (ECLAMC) at the University of Chile Clinical Hospital. A sample of 383 mothers with a chronic disease was compared with 297 healthy mothers. The presence of congenital malformations in the newborns was studied. The odds ratio (OR) of a mother to have a child with a congenital malformation was calculated. Results: Mothers with bronchial asthma, diabetes mellitus, hypertension and hypothyroidism had an OR over 1 of having a child with a congenital malformation. No association between maternal obesity and offspring malformations was observed. Offspring of diabetic mothers had 8.95 times more probabilities of having a major malformation and 4.95 times more probabilities of having a minor defect. Conclusions: Offspring of mothers with diabetes mellitus, bronchial asthma, hypertension or hypothyroidism have a higher risk of presenting a congenital malformation, when compared with offspring of healthy mothers (Rev Méd Chile 2003; 131: 404-11).
Keywords : Abnormalities; Fetal diseases; Pregnancy; high risk; Pregnancy in diabetes.