Revista médica de Chile
versión impresa ISSN 0034-9887
SCHULIN-ZEUTHEN P, Carolina et al. Precocious puberty in a six years old girl caused by a juvenile granulosa cell ovaric tumor. Rev. méd. Chile [online]. 2003, vol.131, n.1, pp. 71-76. ISSN 0034-9887. doi: 10.4067/S0034-98872003000100011.
A six years old girl consulted due to mammary development. On physical examination, clitoris enlargement and a tumor localized in the abdominal-pelvic region were observed. Hormonal study disclosed elevated testosterone and estradiol levels. On exploratory laparotomy, a right ovarian tumor was observed and a right salpingo-oophorectomy was performed. The contemporary biopsy informed a disgerminoma, leading to a surgical staging of the tumor. The definitive pathological diagnosis was a juvenile granular cell tumor, limited to the ovary. In the postoperative period, estradiol and testosterone levels returned to normal values and the pseudopuberty reverted. The patient did not receive adjuvant treatment and after three years of follow up, there is no evidence of tumor recidivism (Rev Méd Chile 2003; 131: 71-6)
Palabras clave : Granular cell tumor; Ovarian neoplasms; Puberty, precocious.