Revista médica de Chile
versión impresa ISSN 0034-9887
CAVAGNARO SM, Felipe y TALESNIK G., Eduardo. Anti neutrophil cytoplasmic antibody (ANCA) positive crescentic glomerulonephritis in children.: Report of two cases . Rev. méd. Chile [online]. 1999, vol.127, n.8, pp. 970-976. ISSN 0034-9887. doi: 10.4067/S0034-98871999000800012.
Anti neutrophil cytoplasmic antibodies are associated to vasculitis and crescentic glomerulonephritis in adults. However, this association has been seldom reported in children. We report two girls aged 12 and 15 years old with ANCA + glomerulonephritis. Both were subjected to a percutaneous kidney biopsy. One girl had to enter a chronic hemodialysis program. The other patient recovered her renal function and after 12 months of treatment with steroids and cyclophosphamide microscopic hematuria and proteinuria persist but with normal kidney function. ANCA should be measured in children with vasculitis and glomerulonephritis
Palabras clave : Antibodies, ANCA; Glomerulonephritis; Neutrophil activation; Vasculitis.